|
Wolf-Hirschhorn Syndrome
|
0.040 |
Biomarker
|
disease |
BEFREE |
Case subjects with der(4) have the Wolf-Hirschhorn syndrome, whereas case subjects with der(8) show a milder spectrum of dysmorphic features.
|
12058347 |
2002 |
|
Wolf-Hirschhorn Syndrome
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We describe a child with Wolf-Hirschhorn syndrome with the karyotype 45,XY,inv(9)(p11q13)pat,-4,-21,+der(4),t(4;21)(p15.3;q11.2)mat.
|
4014316 |
1985 |
|
Wolf-Hirschhorn Syndrome
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The t(4;14) translocation occurs frequently in multiple myeloma (MM) and results in the simultaneous dysregulated expression of 2 potential oncogenes, FGFR3 (fibroblast growth factor receptor 3) from der(14) and multiple myeloma SET domain protein/Wolf-Hirschhorn syndrome candidate gene 1 from der(4).
|
11157491 |
2001 |
|
Wolf-Hirschhorn Syndrome
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These chromosome rearrangements include a marker derived from chromosome 3(cen-q11), an interstitial deletion of chromosome 13 [del(13)(q14q22)], an unbalanced translocation [46,XY, -4, +der(4)t(4;8)(p 15.2;p21.1)] leading to Wolf-Hirschhorn syndrome, and a partial inverted duplication in conjunction with a partial deletion of chromosome 5p [46,XX, -5, +der(5)(:p13-p15.1::p15.1-qter)] which is responsible for the manifestation of the cri-du-chat syndrome.
|
8938060 |
1996 |
|
Wheezing
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Intermediate-onset wheeze was associated with SNPs in several genes in the IL33-IL1RL1 pathway after applying multiple testing correction in the meta-analysis: 2 IL33 SNPs (rs4742170 and rs7037276), 1 IL-1 receptor accessory protein (IL1RAP) SNP (rs10513854), and 1 TRAF6 SNP (rs5030411).
|
24568840 |
2014 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation.
|
31061143 |
2019 |
|
Ureteral obstruction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Compared with non‑obstructed kidneys, the expression levels of IL‑33 and its receptor, interleukin 1 receptor like 1, increased after UUO.
|
31173201 |
2019 |
|
Undifferentiated leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we use Cbfb-MYH11 knock-in mice to show that IL1RL1 is expressed by cell populations with high LSC activity, and that the cell surface expression of IL1RL1 is dynamic, implying that the expression of IL1RL1 is not restricted to a specific stage of differentiation.
|
30742053 |
2019 |
|
Ulcerative Colitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Upon genotype-phenotype evaluation, an increased frequency of extensive colitis in adult UC (P = 0.019) and in steroid-responsive pediatric patients (P = 0.024) carrying the IL-33 rs3939286 risk genotype, was observed. mRNA expression of IL-33 and IL1RL1 in inflamed IBD biopsy samples was significantly increased.
|
23634226 |
2013 |
|
Ulcerative Colitis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Sequencing of a distal IL1RL1 promoter region demonstrated that SNPs rs6543115(C) and rs6543116(A) are associated with increased sST2 in UC patients on corticosteroids.
|
28860510 |
2017 |
|
Ulcerative Colitis
|
0.030 |
Biomarker
|
disease |
BEFREE |
This review summarizes the role of the IL-33/ST2L axis in the UC and CRC microenvironments.
|
29329638 |
2019 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we find that IL-33 and its receptor ST2L are upregulated in the human GC and served as prognostic markers for poor survival of GC patients.
|
31659258 |
2020 |
|
ST-segment elevation myocardial infarction (STEMI)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The association of soluble interleukin-1 receptor-like 1 (ST2) with left ventricular (LV) remodeling is unclear in patients with a first ST-segment elevation myocardial infarction (STEMI).
|
29954670 |
2018 |
|
ST segment elevation myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
We prospectively evaluated 109 patients with a first STEMI treated with primary percutaneous coronary intervention who had ST2 assessed 24 h post-reperfusion.
|
29954670 |
2018 |
|
Skin lesion
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We found that IL-33/ST2L were positively expressed in the skin lesions of AD patients and a high expression of IL-33 was induced in keratinocytes by IL-4 plus interferon [IFN]-γ or IFN-γ alone at the mRNA and protein levels.
|
27348082 |
2016 |
|
Severe Dengue
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High values of IL-6, sTNFRI, sTNFRII and sST2 were observed in DWWS and/or SD and IL-12 and sTRAIL in DNWS.
|
24606681 |
2014 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma.
|
14991091 |
2004 |
|
Schistosomiasis japonica
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Herein, we investigated the role of IL-33 and its receptor ST2L in hepatic granuloma pathology induced by Schistosoma japonicum infection.
|
27445267 |
2016 |
|
Sacral Chordoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic analysis of a sacral chordoma from a 70-year-old male revealed the following chromosomal complement: 42,XY,add(1)(p11), -3,der(4)t(4;?;?18;?)(q12;?;?;), -6, -9, -14,der(16) t(4;?;16)(q12;?;q11), der(17)add(17)(p12) t(17;18)(q11;p11),der(18)del(18)(p11)add(18)(q?)[6]/42, idem,der(9)t(6;9)(q11;p11)[4]/46,XY[10].
|
8039159 |
1994 |
|
Respiratory Tract Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Previous infection with RSV attenuated IL-33 production in lung tissue and reduced relative ST2L expression in lung ILC2s, meaning that previous infection with RSV may alter ILC2 function via the IL-33/ST2 signaling pathway.
|
30027786 |
2018 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
While these cells give rise to multiple cell types, the ST2 (Il1rl1)-expressing group 2 innate lymphoid cells (ILC2s) derived from BM progenitors have been implicated in tissue repair and remodeling, including in lung fibrosis.
|
29722022 |
2018 |
|
Pulmonary Eosinophilia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inflammasome proteins nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 (NLRP1), NLRP3, and nucleotide-binding oligomerization domain (NOD)-like receptor C4 (NLRC4) were associated with neutrophilic asthma and with sputum IL-1β protein levels, whereas eosinophilic asthma was associated with an IL-13-induced T<sub>H</sub>2 signature and IL-1 receptor-like 1 (IL1RL1) mRNA expression.
|
28528200 |
2018 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interleukin-33 enhances programmed oncosis of ST2L-positive low-metastatic cells in the tumour microenvironment of lung cancer.
|
26775708 |
2016 |
|
Peritoneal dissemination
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, silencing of IL-33 expression in CAFs or ST2L expression in GC cells inhibits the peritoneal dissemination and metastatic potential of GC cells in nude mice.
|
31659258 |
2020 |